OBJECTIVE

2

To analyze the status quo， influential factors of medication compliance and adverse drug reactions of home-based patients with severe mental disorders.

METHODS

2

Patients with severe mental disorders at home who were enrolled in the Shanghai mental health information management system in Jinshan district of Shanghai in Jan. 2022 were selected as the research objects. In combination with the relevant basic data registered in the information system and through face-to-face or telephone surveys by mental health doctors， basic information， medication compliance， mental symptoms， social function defects， drug use information and adverse drug reactions of patients were understood. Univariate and multivariate Logistic regression analysis of medication compliance were performed.

RESULTS

2

Totally 2 684 questionnaires were distributed and 2 606 valid questionnaires were recovered， with an effective recovery rate of 97.10%. The overall medication compliance of patients with severe mental disorders at home was 68.11%. The

results of multivariate Logistic regression analysis showed that 51-60 years old， unmarried， divorced or widowed， partial social function defects， no social function defects， and use of third-generation antipsychotic drugs were the promotion factors of medication compliance （

P

＜0.05）； medical insurance， non participation in work， total number of hospitalizations of 1-4 times， total number of hospitalizations ≥ 5 times， general mental symptoms， and use of second-generation antipsychotic drugs were the obstacles to medication compliance （

P

＜0.05）. The incidence of adverse drug reactions in patients with severe mental disorders at home was 10.59%， mainly caused by second-generation antipsychotic drugs， and no new and serious adverse reactions were reported.

CONCLUSIONS

2

The medication compliance of patients with severe mental disorders at home is affected by many factors. It is urgent to need pharmacists’ participation to promote the standardization and rationality of patients’ medication.