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1.安徽中医药大学第四临床医学院(六安市中医院)重症医学科,安徽 六安;237000
2.安徽中医药大学第四临床医学院(六安市中医院)药剂科,安徽 六安 237000
3.无锡市锡山人民医院鹅湖分院中医科,江苏 无锡 214116
主治医师。研究方向:药物临床研究与评价。电话:0564-3318917。E-mail:xu131406@163.com
主治医师,硕士。研究方向:医学方法学。电话:0510-88741237。E-mail:568832807@qq.com
收稿日期:2023-08-18,
修回日期:2024-01-13,
录用日期:2024-01-15,
纸质出版日期:2024-04-15
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徐保平,彭怀文,喻怀斌,等.贝伐珠单抗致罕见严重不良反应糖尿病酮症酸中毒的个案分析[J].中国药房,2024,35(07):877-880.
XU Baoping,PENG Huaiwen,YU Huaibin,et al.Rare and severe adverse reaction diabetic ketoacidosis induced by bevacizumab: one case report[J].ZHONGGUO YAOFANG,2024,35(07):877-880.
徐保平,彭怀文,喻怀斌,等.贝伐珠单抗致罕见严重不良反应糖尿病酮症酸中毒的个案分析[J].中国药房,2024,35(07):877-880. DOI: 10.6039/j.issn.1001-0408.2024.07.19.
XU Baoping,PENG Huaiwen,YU Huaibin,et al.Rare and severe adverse reaction diabetic ketoacidosis induced by bevacizumab: one case report[J].ZHONGGUO YAOFANG,2024,35(07):877-880. DOI: 10.6039/j.issn.1001-0408.2024.07.19.
目的
2
为肿瘤患者安全使用贝伐珠单抗提供参考。
方法
2
回顾分析1例 65岁肺腺癌女性患者使用贝伐珠单抗治疗致糖尿病酮症酸中毒(DKA)的诊疗经过,结合文献复习分析其可能的发生机制和原因。
结果与结论
2
分析患者诊疗经过,排除其他药物和疾病因素导致的DKA;依据诺氏药物不良反应评估量表,考虑DKA为使用贝伐珠单抗所致,予血液透析治疗1次后患者酸中毒迅速改善。贝伐珠单抗致 DKA属临床罕见不良反应,临床医师需意识到贝伐珠单抗可能影响胰腺功能,诱发DKA,应做到早期发现和处理,从而改善患者预后。
OBJECTIVE
2
To provide reference for the safe use of bevacizumab in cancer patients.
METHODS
2
The diagnosis and treatment of a 65-year-old female lung adenocarcinoma patient with diabetic ketoacidosis (DKA) induced by bevacizumab was retrospectively analyzed, and the possible mechanisms and causes were analyzed based on literature review.
RESULTS &CONCLUSIONS
2
The diagnosis and treatment process of patients were analyzed, and DKA caused by other drugs and disease factors were excluded. DKA was considered to be caused by the use of bevacizumab according to Naranjo’s ADR evaluation scale; the acidosis of the patient improved rapidly after one hemodialysis treatment. DKA caused by bevacizumab is rare in clinic, clinicians should be aware that bevacizumab may affect pancreatic function and induce DKA, and early detection and treatment should be achieved to improve the prognosis.
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