倍半萜类化合物抗肝癌作用机制研究进展

毛景欣; 杜鑫; 李艳

doi:10.6039/j.issn.1001-0408.2025.03.21

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倍半萜类化合物抗肝癌作用机制研究进展

综述 | 更新时间：2025-02-10

- 倍半萜类化合物抗肝癌作用机制研究进展
- Research progress on the mechanism of sesquiterpenoids against hepatocellular carcinoma
- 中国药房 2025年36卷第3期页码：379-384
- 作者机构：
  
  1.重庆医药高等专科学校科技产业发展中心，重庆　401331
  2.毒性中药给药系统重庆市重点实验室，重庆　401331
- 作者简介：
  
  博士。研究方向：生物药学。E-mail：2230040@ cqmpc.edu.cn
  副教授。研究方向：中药成分分析及药理作用机制。E-mail：10864@cqmpc.edu.cn
- 基金信息：
  
  重庆市自然科学基金面上项目(CSTB2023- NSCQ-MSX0393)
- DOI：10.6039/j.issn.1001-0408.2025.03.21
  中图分类号： R285;O629.6+1
- 纸质出版日期：2025-02-15，
  
  收稿日期：2024-12-05，
  
  修回日期：2025-01-07，
  
  录用日期：2025-01-13
- 稿件说明：
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毛景欣,杜鑫,李艳.倍半萜类化合物抗肝癌作用机制研究进展 ^Δ[J].中国药房,2025,36(03):379-384.

MAO Jingxin,DU Xin,LI Yan.Research progress on the mechanism of sesquiterpenoids against hepatocellular carcinoma[J].ZHONGGUO YAOFANG,2025,36(03):379-384.
毛景欣,杜鑫,李艳.倍半萜类化合物抗肝癌作用机制研究进展 ^Δ[J].中国药房,2025,36(03):379-384. DOI： 10.6039/j.issn.1001-0408.2025.03.21.

MAO Jingxin,DU Xin,LI Yan.Research progress on the mechanism of sesquiterpenoids against hepatocellular carcinoma[J].ZHONGGUO YAOFANG,2025,36(03):379-384. DOI： 10.6039/j.issn.1001-0408.2025.03.21.

摘要

肝癌作为世界上较为常见的实体器官恶性肿瘤之一，其在我国的发病率已攀升至第4位，病死率居第2位，严重威胁着人民的健康。萜类化合物是自然界中广泛存在的天然活性物质，其中倍半萜类化合物数量众多，它们展现出多种药理活性，如抗肿瘤、抗菌、抗炎、抗病毒及抗氧化等。本文对倍半萜类化合物2015－2024年抗肝癌作用机制研究进展进行综述。结果显示，近10年文献报道了24种用于治疗肝癌的倍半萜类化合物，这些化合物通过抑制癌细胞增殖、诱导凋亡、阻止侵袭转移、调节免疫及增强抗耐药性等途径展现出治疗肝癌的潜力。这些机制主要涉及三大调控路径：磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路、核因子κB信号通路、线粒体途径。未来，需继续探索新的有较高研究价值的抗肝癌药物，深入分析多成分、多靶点、多途径协同抗肝癌的作用机制，并加速成品研发，以期在临床中广泛应用。

Abstract

As one of the most common solid organ malignant tumors in the world， hepatocellular carcinoma has climbed to the fourth place in incidence rate and the second place in mortality in China， which seriously threatens people’s health. Terpenoids are natural active substances widely present in nature， among which sesquiterpenoids are numerous. They exhibit a variety of pharmacological activities， such as anti-tumor， antibacterial， anti-inflammatory， antiviral and antioxidant activities. This article reviews the research progress on the anti-hepatocellular carcinoma mechanism of sesquiterpenes from 2015 to 2024. The results showed that 24 sesquiterpenoids for the treatment of hepatocellular carcinoma have been reported in the literature in the past 10 years， and these compounds have shown potential in treating hepatocellular carcinoma by inhibiting cancer cell proliferation， inducing apoptosis， preventing invasion and metastasis， regulating immunity， and enhancing anti-drug resistance. The mechanism of anti-hepatocellular carcinoma mainly involves three regulatory pathways: phosphatidylinositol 3-kinase/protein kinase B/ mammalian target of rapamycin signaling pathway， nuclear factor kappa-B signaling pathway， and mitochondrial pathway. In the future， it is necessary to continue to explore new anti-hepatocellular carcinoma drugs with high research value， conduct in-depth analysis on the mechanism of synergistic anti-hepatocellular cancer effects of multiple components， targets， pathways， and accelerate the development of finished products in order to be widely used in clinical practice.

关键词

倍半萜类化合物肝癌药理作用作用机制

Keywords

hepatocellular carcinomapharmacological actionmechanism

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