OBJECTIVE： To provide reference for enhancing and standardizing the storage， dispensing and clinical use of the photophobic drug. METHODS： The management system and directory of photophobic drugs were set up in our hospital， and photophobic drug were classified into drugs used away from light strictly and drugs used away from light appropriately. Special training for nursing staff and monthly inspection of photophobic drug storage and use by inspection group could help finding problems and doing timely rectification. The number of wards where the problems of clinical photophobic drug use were found were compared before and after management. RESULTS & CONCLUSIONS： After 3-quarter management， the quantity of wards with problems decreased from 69 to 2， decreasing by 97.1％. The management reinforce of photophobic drug can effectively promote the management of drugs to be standard and scientific and improve the safety and effectiveness of photophobic drug use.