OBJECTIVE：To provide reference for helping poor patients with chronic diseases to get rid of poverty and enjoy drug welfare. METHODS ：A overall general questionnaire was designed and conducted in Lianyungang City and Changzhou City of Jiangsu Province ，and then conducted formal investigation in Gansu ，Hebei and Sichuan. Factor analysis was used to analyze the survey results ，and the drug welfare effects of 4 kinds of chronic diseases were scored ，the difference and main influential factors of drug welfare effect for different chronic disease patients were found out. RESULTS ：A total of 745 questionnaires were sent out ， and 721 effective questionnaires were finally collected ，with an effective recovery rate of 96.8％. Factor analysis results showed that the drug welfare effect of patients with chronic diseases can be divided into 5 dimensions such as drug health effect ，drug fair effet，drug price effect ，drug availability effect and personal economic level effect. The average score of comprehensive drug welfare effect of chronic disease patients was 2.56（general）. The average scores of comprehensive drug welfare effects in patients with diabetes，cardiovascular and cerebrovascular diseases ，chronic respiratory system diseases and malignant tumors were 3.12（good）， 2.73（general），2.56（general）and 1.90（poor）. The key factors influencing the drug welfare of the patients with chronic diseases were health effect ，drug fair effect ，and drug price effect. CONCLUSIONS ：In formulating relevant policies ，the state should take drug health effect ，drug fair effect ，drug price effect and drug availability of chronic diseases into consideration ，and formulate more comprehensive and effective drug policy.