OBJECTIVE：To establish a method for sim ultaneous determination of 7-hydroxycoumarin，6，7-dimethoxy- coumarin，5，7-dimethoxycoumarin，imperatorin and bergaptene in Shugan hewei pills. METHODS ：Samples were extracted by Soxhlet extraction and separated by using D 101 macroporous adsorption resin ；HPLC method was used to determine the contents of above 5 components. The determination was performed on Venusil MP C 18 column with mobile phase consisted of methanol- 0.1％ phosphoric acid water solution （gradient elution ）at the flow rate of 1.0 mL/min. The detection wavelength was 270 nm and the column temperature was 30 ℃ . The sample size was 10 μ L. RESULTS：The linear ranges were 1.875-187.5 μ g/mL for 7-hydroxycoumarin（r＝0.999 9），1.075-107.5 μg/mL for 6，7-dimethoxycoumarin（r＝0.999 9），1.261-126.1 μg/mL for 5， 7-dimethoxycoumarin（r＝0.999 9），0.875-87.5 μg/mL for imperatorin（r＝0.999 9），2.033-203.3 μg/mL for bergaptene（r＝0.999 8）， respectively. RSDs of precision ，stability（24 h），reproducibility and durability tests were lower than 2.0％. Average recoveries were 95.18％ -98.44％ （RSD＝1.27％ ，n＝6）， 95.35％ -98.14％ （RSD＝1.16％ ，n＝6），95.21％ -97.32％ （RSD＝0.83％ ，n＝6）， 95.43％-97.14％（RSD＝0.76％，n＝6），95.12％-98.75％（RSD＝1.35％，n＝6），respectively. The average contents of the above five components in 3 batches of shugan hewei pills were 0.424，0.239，0.305，0.180，0.459 mg/g（n＝2）.CONCLUSIONS：A method for simultaneous determination of five components in Shugan hewei pills was established.