OBJECTIVE：To explore the protective effect of Alpinia zerumbet extract on acute gastric ulcer model mice. METHODS：Totally 48 mice were collected and randomly divided into blank group ，model group ，positive group （Sanjiu weitai granules，20 mg/kg），A. zerumbet extract high-dose ，medium-dose and low-dose groups （2.34，1.17，0.59 g/kg，by crude drug ）， with 8 mice in each group. They were given normal saline or relevant medicine intragastrically ，once a day ，for consecutive 7 d. Then，except for blank group ，other groups were given disposable intragastric administration of absolute ethanol 0.1 mL/10 g to establish acute gastric ulcer model. Another 48 mice were collected and grouped with same method ，and then given relevant medicine for consecutive 15 d. From the 10th day of administration ，except for blank group ，other groups were given intragastric administration of aspirin （20 mg/kg） for consecutive 6 d to establish acute gastric ulcer model. In ethanol induction model experiment，the formation of gastric ulcer and the index of gastric ulcer were observed in each group ；HE staining was used to observe the pathological changes of gastric tissue ；the levels of gastrin （GAS）in serum ，and the levels of SOD ，MDA and NO in gastric tissue were determined by ELISA. In the aspirin induced model experiment ，the formation of gastric ulcer and the index of gastric ulcer were observed and measured by the same method ；the levels of GAS ，TNF-α，IL-1β in serum，and the levels of PGE2 and COX- 2 in gastric tissue were determined by ELISA. RESULTS ：Compared with model group ，obvious ulcer lesions were found in gastric tissue of rats in model group ；the levels of GAS ，TNF-α，IL-1β in serum，and MDA ，NO in gastric tissue were increased significantly ， while the levels of SOD ， PGE2， （No.QZYY-2019- COX-2 in gastric tissue were decreased si gnificantly（P＜0.05 063）. Compared with model group ，the degree of gastric lesions in administration groups was alleviated to some extent；gastric ulcer index was decreased to some extent ， mail：997845460@qq.com while the levels of the above indexes in serum and gastric tissue were improved in varying degrees ， with statistical 制。E-mail：672863283@qq.com significance in most indexes （P＜0.05 or P＜0.01）. CONCLUSIONS：A. zerumbet extract exerts its protective effect on absolute ethanol and a spirin-induced acute gastric ulcer model mice，the mechanism of which may be relieving gastric mucosal injury through inhibiting oxidative stress and inflammatory response.