OBJECTIVE：To pr ovide refe rence for the future research on drug safety legislation and scientific law enforcement and justice. METHODS ：The journal articles published from Jan. 1st，1985 to Dec. 31st，2019 in CNKI were searched by using “subject＝drug crime ，food and drug crime or drug and criminal law ”as retrieval words but without “subject＝drug”. By screening literature，with the emphasis on the content ，with the help of CiteSpace 5.6.R4 software，the legislative dynamics of drug safety and typical drug injury events in China were sorted out and analyzed. The development of the research on drug safety crimes in China were analyzed from four aspects ：research output ，research academic groups ，research discipline perspective and research focus. From the aspects of criminal policy ，criminal legislation ，major drug injury cases ，administrative supervision concept and administrative legislation ，the factors influencing the research changes in each stage were combed and excavated ；on this basis ，the relevant researches on drug safety crime were reviewed and suggestions were put forward for its improvement path. RESULTS & CONCLUSIONS：A total of 852 literatures were retrieved ，and 473 valid literatures were included. The research on crimes against drug safety in China has gone through the exploration period （1985-1996），transition period （1997-2010）and vigorous period （2011-2019）. The number of achievements has been increasing ，and the scale of academic groups has continued to expand ， forming a discipline distribution with criminal law research as the main research ，public security science research as the auxiliary ， and natural science research as the foreign aid ，focusing on the issues of legislation ，judicature and criminal law value ，for example，various academic researches was conducted with major hazardous drug cases as the breakthrough point. Among the influential factors of the researches on drug safety crime ，criminal policy and legislation ，administrative legislation and regulatory evolution were the internal logic ，and the sudden drug injury cases were the important external factors. For this purpose ，to promote theoretical innovation and practical exploration of drug safe ty crime research ，research on drug safety crime in the future should focus on the whole chain of drug safety ， using method and empirical research methods.