OBJECTIVE：To provide reference for accelerating the process of prescription outflow in China by using “Internet+ medicare”. METHODS ：Based on stakeholder perspective ，the stakeholder model of prescription outflow was constructed under the background of “Internet + ”. By analyzing stakeholders （hospital，patient，government，drugstore and third-part consultation platform）who impeded the prescription outflow and their demands ，the obstacles and causes of promoting prescription outflow under the background of “Internet+”were summarized to put forward relevant countermeasures and suggestions. RESULTS & CONCLUSIONS：“Internet+Medicare”accelerated the process of prescriptions outflow by improving the convenience in each links of medical treatment ，but there were still obstacles in prescription source ，patient flow ，supporting policies and system construction to continue promoting prescription outflow. The reason lied in the pressure of hospital operation and the diagnosis demand of doctors；the treatment demand of patients could not be satisfied by the receiving party of prescription outflow ；the difficulty of government supervision and system construction ；immature supervision mode of the third-party consultation platform and online pharmacies，and the platform technology research and development to be break through. To continue promoting prescription outflow under the background of “Internet + ”needs to strengthen top-level design ，establish supporting systems ，break the regional restrictions，build a unified and standardized prescription circulation information platform ；formulate the prescription outflow assessment standard and encouragement mechanism of hospital ，enhance the ability of the third-part platforms and pharmacies to undertake the prescription ，strengthen the publicity and education of patients ，enhance their channel awareness and risk awareness. The exploration mode of prescription outflow in which all stakeholders develop together and cooperate with each other is formed finally so as to promote the outflow of prescription.