OBJECTIVE： To improve the proper use of proton pump inhibitors （PPIs） and develop prescription pre-review. METHODS： Among “Hospital Self-Maintenance Rule Base” of “Rational use of drug” in our hospital， according to the application of PPIs in our hospital， the dosage of PPIs under different indications， drug combination， age range and taboo level for children were refined to promote the prescription pre-review. After refinement， the qualified rate of PPIs prescription post-evaluation among outpatient prescriptions， successful rate of pharmacist intervention during pre-prescription review and unqualified prescription rate of each item for 8 PPIs （including “interaction” “clinical diagnosis does not conform to medication” “repeated administration” “inappropriate usage”） were analyzed statistically from Jan. to Aug. 2018. The effects of fined setting were evaluated. RESULTS： From Jan. 2018 to Aug. 2018， the qualified rate of PPIs prescription post-evaluation gradually increased from 81.94％ to 95.10％； successful rate of pharmacist intervention during pre-prescription review increased from 32.75％ to 91.01％； the rate of unqualified prescriptions for 4 items decreased significantly month by month. CONCLUSIONS： The fine setting of the rules for the use of proton pump inhibitors in our hospital has effectively carried out the pre-examination of outpatient prescriptions and promoted the rational use of PPIs.