OBJECTIVE： To establish a method for simultaneous determination of 7 indicator components in Cortex Moutan by different processing methods， and to evaluate the quality of them. METHODS： HPLC method was adopted to determine the contents of 7 indicator components in Cortex Moutan by different proessing methods. The determination was performed on ZORBAX Eclipse XDB-C18 column with mobile phase consisted of methanol-0.1％ phosphoric acid solution（gradient elution） at the flow rate of 1 mL/min. The detection wavelengths were set at 230 and 258 nm. The sample size was 10 μL and the column temperature was 30 ℃. The content of ethanol-soluble extract was determined by the method included in Chinese Pharamacopoeia. The quality evaluation model of Cortex Moutan material/decoction piece was established using 7 kinds of indicator components and ethanol-soluble extract as evaluation index， relative correlation degree as measurement. The quality of Cortex Moutan was evaluated. RESULTS： The linear range of gallic acid， catechin， oxidation paeoniflorin， paeoniflorin， benzoic acid， paeonol and enzoyl paeoniflorin were 0.002-0.034 μg（r＝0.999 9）， 0.003-0.045 μg（r＝0.999 9）， 0.013-0.189 μg（r＝0.999 8）， 0.019-0.291 μg（r＝0.999 9）， 0.002-0.030 μg（r＝0.999 9）， 0.050-0.752 μg（r＝0.999 9） and 0.005-0.076 μg（r＝0.999 8）. The limits of quantitation were 1.213， 1.380， 1.307， 1.178， 0.275， 1.538， 0.870 ng， respectively. The detection limits were 0.364， 0.414， 0.392， 0.354， 0.083， 0.461， 0.261 ng， respectively. RSDs of precision， stability and repeatability test were all less than 3 ％. The recovery rates were 101.00％-105.20％（RSD＝1.69％，n＝6）， 96.01％-104.14％（RSD＝2.77％，n＝6）， 93.60％-99.87％（RSD＝2.15％，n＝6）， 95.84％-97.39％（RSD＝0.61％，n＝6）， 95.74％-99.31％（RSD＝1.45％，n＝6）， 98.65％-100.80％（RSD＝0.69％，n＝6）， 101.87％-107.07％（RSD＝2.44％，n＝6）， respectively. The relative correlation of Cortex Moutan by different processing method was 0.396-0.590. The order of the quality of all processed samples was： the original medicinal materials of Cortex Moutan that retained both cork and xylem（0.590） ＞ the original medicinal materials of Cortex Moutan that removed both cork and xylem（0.532） ＞ the fresh-cut slice of Cortex Moutan that retained cork but romoved xylem（0.523） ＞ the original medicinal materials of Cortex Moutan that retained cork but removed xylem（0.522） ＞ the fresh-cut slice of Cortex Moutan that removed both cork and xylem（0.502） ＞ the original medicinal materials of Cortex Moutan that removed cork but retained xylem（0.420） ＞ the fresh-cut slice of Cortex Moutan that removed cork but retained xylem（0.409） ＞ the fresh-cut slice of Cortex Moutan that removed both cork and stayed xylem（0.396）. As a whole， the quality of the samples of Cortex Moutan which had retained cork was higher than the quality of the samples of Cortex Moutan which had removed cork. CONCLUSIONS： HPLC method is accurate， reliable and repeatable for simultaneous determination of 7 indicator components in Cortex Moutan by different processing methods. Grey correlation degree method can be used for evaluating the quality of Cortex Moutan by different processing methods. The two methods of “fresh-cut slice of Cortex Moutan that retained cork but removed xylem” and “original medicinal materials of Cortex Moutan that retained cork but removed xylem” can be used to process fresh Cortex Moutan in habitats.