OBJECTIVE： To evaluate the effectiveness and economical efficiency of Mailuoning injection and Compound danshen injection in the treatment of ischemic stroke. METHODS： Using “Mailuoning injection” “Compound danshen injection” “Compound danshen for injection” “cerebral infarction” and “ischemic stroke” as Chinese keywords，  “Mailuoning injection” “Compound danshen injection” “Compound salvia miltiorrhiza injection” “cerebral infarction” and “cerebral ischemic stroke” as English keywords， RCTs about Mailuoning injection and Compound danshen injection in the treatment of ischemic stroke were retrieved from CNKI， Wanfang database， VIP and PubMed by means of logical operator combined with literature tracing and manual retrieval during the date of database establishment to Feb. 2018. RevMan 5.3 software was used for Meta-analysis of total response rate of 2 kinds of therapy plans. The decision tree model was used for pharmacoeconomics analysis. Cost-effectiveness ratio （CER） and incremental cost-effectiveness ratio （ICER） of two therapy plans were calculated. Sensitivity analysis was conducted by reducing 20％ cost of drugs and fluctuating by 5％ up and down of effectiveness. RESULTS： A total of 7 RCTs were included， involving 510 patients. The results of Meta-analysis showed that the total response rate of Mailuoning injection was better than that of Compound danshen injection [OR＝5.14， 95％CI （2.83，9.34）， P＜0.001]. Results of decision tree model analysis showed that the cost of Compound danshen injection was lower than that of Mailuoning injection （168 yuan vs. 394 yuan）； CER of Mailuoning injection and Compound danshen injection were 4.18 and 2.21； ICER of Mailuoning injection was 12.4， compared with Compound danshen injection. ICER was lower than GDP per capita in 2016 （53 935 yuan）. The results of sensitivity analysis did not affect the conclusion. CONCLUSIONS： Compared with Compound danshen injection， Mailuoning injection is more effective for ischemic stroke and more economical.