OBJECTIVE： To explore the rationality of TCM injection， and to provide reference for optimizing the development of TCM injection. METHODS： Through literature research， the origin and development of TCM injections were systematically reviewed； the security problems of TCM injections and their causes were deeply analyzed； based on the characteristics and historical experience of TCM injections， their rationality was explored， so as to put forward specific suggestions. RESULTS： TCM injections still had safety problems due to their own technical problems， irregular circulation and storage links， unreasonable clinical use， individual differences among patients， lack of monitoring and management mechanisms. But from the perspectives of product technology， clinical efficacy， clinical demand and the development of TCM， the existence of TCM injections was reasonable and necessary. CONCLUSIONS： The rational development and use of TCM injections throughout the life cycle are strengthened from the perspectives of R&D and production， marketing， clinical use， and monitoring management. Meanwhile， technical assessment of TCM injections is carried out comprehensively to promote their survival of the fittest and healthy development. It is suggested to establish and improve the rescue mechanism for personal injury of TCM injections， and protect patients’ rights.