OBJECTIVE： To systematically review therapeutic efficacy of Compound danshen dripping pill combined with angiotensin Ⅱ receptor blocker versus angiotensin Ⅱ receptor blocker alone for diabetic nephropathy， and to provide reference for clinical use. METHODS： Retrieved from PubMed， Cochrane library， Embase， CNKI， VIP， Wanfang database and CBM from database establishment to June 2， 2018， RCTs about Compound danshen dripping pills combined with angiotensin Ⅱ receptor blocker （trial group） versus angiotensin Ⅱ receptor blocker alone （control group） for diabetic nephropathy were collected. After data extraction of included literatures， quality evaluation was performed by using Cochrane system evaluator manual 5.0.1. Meta-analysis was performed for the decrease degree of serum creatinine， urinary protein excretion rate level， blood lipid （TC， TG， LDL-C）， 2 h postprandial blood glucose and microalbuminuria by using Stata 14.0 software. RESULTS： There were 12 RCTs， including 882 patients. Results of Meta-analysis showed that the decrease degree of urinary protein excretion rate level [WMD＝－18.54，95％CI（－23.67，－13.40）， P＜0.001]， serum creatinine [WMD＝－5.28，95％CI（－10.22，－0.35）， P＜0.001]， TC [WMD＝－1.70，95％CI（－2.53，－0.87）， P＜0.001]， TG [WMD＝－0.88，95％CI（－1.26，－0.49）， P＜0.001]， LDL-C [WMD＝－0.57，95％CI（－1.09，－0.05）， P＜0.001]， 2 h postprandial blood glucose [WMD＝－0.43，95％CI（－0.92，－0.05）， P＜0.001]， microalbuminuria [WMD＝－13.73，95％CI（－20.73，－6.73）， P＜0.001] in trial group were better than that in control group. CONCLUSIONS： Compared with angiotensin Ⅱ receptor blocker alone， Compound danshen dripping pill combined with angiotensin Ⅱ receptor blocker can significantly improve serum creatinine， urinary protein excretion rates， TC， TG， LDL-C， 2 h postprandial blood glucose and microalbuminuria in patient with diabetic nephropathy.