OBJECTIVE： To optimize the extraction technology of Shegui zhiyang formula. METHODS： The extraction technology route （4 technologies such as ethanol extraction， water extraction， etc.） of Shegui zhiyang formula in mice was screened by using related indexes of antipruritic efficacy test. Using comprehensive score of extract yield， the contents of ferulic acid， paeoniflorin， matrine and oxymatrine as indexes， L9（34） orthogonal test was used to screen optimal parameters of extraction technology as volume fraction of ethanol， ethanol fold， extraction time （times）. Validation test was conducted. RESULTS： Screened extraction technology route was medicinal materials were reflux extracted with 60％ ethanol. The optimal technology included extracting for 2 times， lasting for 2 h with 8-fold ethanol at first time， lasting for 1 h with 8-fold ethanol at second time. The results of validation tests showed that average contents of ferulic acid， paeoniflorin， matrine and oxymatrine were 0.71， 22.13， 1.92， 9.88 mg/g （RSD＝2.96％， 2.03％， 2.55％， 1.23％，n＝3）. Average extract yield was 19.22％ （RSD＝0.96％， n＝3）. CONCLUSIONS： The optimized extraction process is stable and feasible.