OBJECTIVE： To establish the method for simultaneous determination of glycyrrhizic acid， salicin， glycyrrhetinic acid， chenopodium， paeonol， imperatorin and isoimperatorin in Fengshiding tablet. METHODS： HPLC-CAD method was adopted. The determination was performed on Thermo Hypersil BDS C18 column with mobile phase consisted of acetonitrile-10 mmol/L ammonium formate （pH value adjusted to 4.5 using formic acid， gradient elution） at the flow rate of 1.0 mL/min. The column temperature was set at 35 ℃. CAD atomizer temperature was 35 ℃， and air pressure was （59.6±0.1） psi. The detection frequency was 10 Hz， and sample size was 20 μL. RESULTS： The linear range of glycyrrhizic acid， salicin， glycyrrhetinic acid， chenopodium， paeonol， imperatorin and isoimperatorin were 0.42-16.80， 0.28-11.20， 0.16-6.20， 0.98-39.40， 1.02-41.00， 0.11- 4.40， 0.10-3.80 μg/mL（r≥0.999 1）， respectively. The detection limits were 0.03， 0.02， 0.02， 0.03， 0.03， 0.02， 0.02 μg/mL， respectively； quantitation limits were 0.11， 0.06， 0.06， 0.10， 0.11， 0.08， 0.07μg/mL， respectively. RSDs of precision， stability （48 h） and reproducibility tests were all lower than 2.0％ （n＝6 or n＝7）. Average recoveries rate were 98.61％-99.76％， and RSDs were 1.11％-1.51％ （n＝6）. CONCLUSIONS： The established method is simple， sensitive， accurate， and can be used for simultaneous determination of glycyrrhizic acid， salicin， glycyrrhetinic acid， chenopodium， paeonol， imperatorin and isoimperatorin in Fengshiding tablet.