OBJECTIVE： To strengthen the management of key monitoring drugs in our hospital， and to control the increase of drug cost. METHODS： The former auxiliary directory was improved， and the key monitoring drugs were managed by formulating regulations and systems as Provisions for Key Monitoring Drug Management in Clinical Departments， constructing Key Monitoring Drugs List， adopting pharmaceutical administration intervention measures， such as establishing key monitoring drug dynamics/early warning monitoring mechanism， implementing responsibility system of key monitoring drug proportion， developing special comment on prescription and medical order， improving policy of awards and penalties， establishing omni-directional and multi-angle control system. The application of key monitoring drugs was analyzed in clinical departments of our hospital during Jan.-Jun. 2017 （before intervention） and Jul.-Dec. 2017 （after intervention）. RESULTS： After intervention， consumption sum of key monitoring drugs decreased by 39.96％， compared with before intervention； the proportion of key monitoring drugs in all drugs decreased by 36.02％ （decreasing from 23.68％ before intervention to 15.15％）. The per capita cost of key monitoring drugs decreased by 48.41％， and drug ratio decreased from 42.93％ to 32.23％. Among top 20 key monitoring drugs in the list of consumption sum， consumption sum of 16 kinds were decreased to different extents. Among 22 departments， the number of clinical departments with the proportion of key monitoring drugs over standard monitoring lines decreased from 20 before intervention to 8. The proportion of key monitoring drugs decreased significantly in most clinical departments. Through special comments， the number of prescriptions and medical orders checking had increased significantly， and the corresponding unreasonable drug use had been found more. CONCLUSIONS： After adopting key monitoring drug management measures in our hospital， drug cost have been greatly reduced， and consumption sum and proportion of key monitoring drugs have been decreased significantly so as to more effectively find out irrationality of drug use and relieve patients’ medical treatment burden.