OBJECTIVE： To provide reference for clinical application and related new drug R&D of the couplet medicines of Platycodon grandiflorum-Glycyrrhiza uralensis. METHODS： All set prescription preparations containing P. grandiflorum-G. uralensis in Ministry of Public Health Drug Standard·TCM Set Prescription Preparation were collected； data mining and analysis for the syndrome and treatment rules of these prescriptions were performed by using TCM Inheritance System V 2.5. RESULTS： There were a total of 315 set prescription preparations containing couplet medicine of P. grandiflorum-G. uralensis， 89 main syndromes and 88 main diseases. Among of them， high frequency major syndrome were exterior syndrome attacked by wind-heat and exterior syndrome tightened by wind-cold， and dominating medicine combination were respectively Yinqiao powder and Xingsu powder. High frequency main diseases were common cold and cough.  Core medicine combination in the treatment of common cold included Yinqiao powder， Xingsu powder， Huoxiang zhengqi powder and Chaihu zhijie decoction， etc. Core medicine combination in the treatment of cough included Xingsu powder， Zhisou powder， Tongxuan lifei pills and Qingjin huatan decoction， etc. CONCLUSIONS： The study confirms the syndrome and treatment rules of set prescription preparations containing couplet medicines of P. grandiflorum-G. uralensis， and could provide evidence for clinical application of the couplet medicines of P. grandiflorum-G. uralensis and new drug R&D.