OBJECTIVE： To summarize the practice of medication consultation service based on the platform of “Our Pharmacist”， and to provide reference for pharmacists participating in pharmaceutical care. METHODS： The 502 medication consultation service for children， pregnant women and lactating women were collected from the platform of “Our Pharmacist” during Oct. 2017-Jul. 2018. General information， main medication， types of drugs， types of questions， types of irrational drug use were analyzed statistically. The practice of rational drug use patient guidance service based on evidence-based concept was introduced with typical examples. RESULTS： Among 502 cases of consultation， 147 （29.3％） were males and 355 （70.7％） were females， and the age was mainly 20-40 years old （291 case， 58.0％）. The proportions of patients taking 1-2， 3-4， 5 types or more drugs were 45.4％， 41.4％ and 13.2％， respectively， and those who took 5 or more drugs at the same time were all children’s patients. In respect of medication consultation content， children medication consultation， pregnant medication consultation and lactating medication consultation accounted for 42.0％， 40.6％， 17.4％， respectively. Antibiotics， Chinese patent medicines and antivirals accounted for the largest proportion of consulting drugs， being 25.6％， 17.8％， 12.1％， respectively. The question types of medication consultation included indication， dosage and course of treatment， drug safety and ADR， accounting for 31.9％， 17.5％， 13.6％， respectively. The types of irrational drug use mainly included improper drug selection， repeated drug use and no indication， accounting for 44.1％， 21.0％， 14.9％， respectively. In typical cases， pharmacists conducted systematic evidence inquiry and answered patient consultation strictly in accordance with the evidence-based concept. The main evidence-based process included formulating retrieval strategies， retrieving relevant literature， strictly evaluating evidence （authenticity， reliability and adaptability）， screening evidence according to its evidence level from high to low， evaluating evidence comprehensively and applying it to practice. Medication guidance information provided by pharmacists based on evidence not only corrected the irrational drug use of patients， but also received good feedback from patients. Five-star score accounts for 95.5％ of the satisfaction evaluation. CONCLUSIONS： Based on evidence-based concept， the platform of “Our Pharmacist” provides medication consultation service， which provides references for pharmacists to carry out targeted pharmaceutical care.