OBJECTIVE： To formulate the quality standard of Andrographis paniculata dispensing granule preliminarily， and to establish its HPLC fingerprints. METHODS： TLC and HPLC method were used for qualitative identification and quantitative analysis of andrographolide and dehydro-andrographolide in Andrographis paniculata dispensing granules. According to 2015 edition of Chinese Pharmacopeia （called “Pharmacopeia” for short）， the moisture， granularity， solubility and extract were determined. HPLC fingerprints of 10 batches of A. paniculata dispensing granule were drawn， and similarity of it with control fingerprint was evaluated. RESULTS： In TLC of test sample， the same spots were found in corresponding position as chromatogram of control sample. The moisture， granularity， solubility and extract of A. paniculata dispensing granule were all in line with the standard of Pharmacopeia. The linear range of andrographolide and dehydro-andrographolide were 10.983-274.583 （r＝0.999 9） and 11.355- 283.886 mg/L （r＝0.999 9）. RSDs of precision tests were 0.50％ and 0.29％（n＝6）. RSDs of reproducibility tests were 0.99％ and 0.51％（n＝6）. RSDs of stability tests were 0.19％ and 0.53％ within 24 h at room temperature（n＝6）. Average recoveries were 99.03％ （RSD＝1.98％， n＝6） and 102.24％（RSD＝1.86％，n＝6）. The contents of andrographolide and dehydro-andrographolide were （12.18±0.16） and （7.53±0.24） mg/g （n＝3）. The similarity of HPLC fingerprints for 10 batches of A. paniculata dispensing granule with control HPLC fingerprints were all higher than 0.99. CONCLUSIONS： Established quality standard and HPLC fingerprint of A. paniculata dispensing granule can be used for quality control of A. paniculata dispensing granule.