OBJECTIVE： To analyze the post antibiotics effect （PAE） by using text mining technology and to provide reference for rational application of antibiotics. METHODS： Using “PAE” “post antibacterial effect” “post antibacterial drug effect” as keywords， PAE antibiotics and related bacterial and the effect of drug combination on PAE， influential factors of PAE duration and clinical application were retrieved from CNKI， Wanfang database， VIP during Jan. 1st， 1996-Oct. 13th， 2017. The suggestions were put for ward rational use of PAE antibiotics. RESULTS： A totally of 349 literatures were included， involving 62 kinds of PAE antibiotics and compounds. PAE antibiotics mainly included β-lactam， aminoglycosides， macrolides， quinolones， amphenicol and other types. Top 10 antibiotics in the list of frequency were ciprofloxacin， amikacin， netilmicin， ofloxacin， azithromycin， gentamycin， gatifloxacin， ceftazidime， cefoperazone and fosfomycin. Top 8 bacterials treated with PAE antibiotics were Escherichia coli， Staphylococcus aureus， Pseudomonas aeruginosa， Enterococcus faecalis， Klebsiella pneumoniae， Staphylococcus epidermidis， drug-resistant Acinetobacter baumanii and Staphylococcus haemolyticus； 27 kinds of drug combination were involved， among which ciprofloxacin+fosfomycin， netilmicin+ceftazidime， amoxicillin+netilmicin were commonly used. Influential factors of PAE duration were in descending order were types of antibiotics， concentration of antibiotics and combined use of antibiotics， types of bacterial and concentration of bacterial， body condition， drug contact time， pharmacokinetic parameters and AUC. Main measures of rational drug use guidance were designing scientific and rational medication plan， adjusting and formulating therapy plan， evaluating new antibiotics. CONCLUSIONS： Text mining technology can be a more objective and systematic summary of PAE regularity， so as to provide a reference for clinical application. Clinicians and pharmacists should design and adjust the treatment plan according to the duration of PAE and pharmacokinetic parameters.