OBJECTIVE： To investigate the potential prevention and treatment mechanism of total flavonoids of Tibetan medicine Hippophae rhamnoidesh （TFH） on chronic bronchitis， and to provide reference for further development and utilization. METHODS： TCM system pharmacology analysis platform database （TCMSP） was used to screen effective components of TFH. PharmMapper network service system， BATMAN-TCM network pharmacology research platform， DrugBank database and OMIM database were all used to predict and match effective components of TFH on the potential target （target gene） of chronic bronchitis. GO enrichment and KEGG pathway annotation analysis were conducted by biomolecular function annotation system 3.0. Cytoscape 3.5.1 software was used to establish TFH “component-target-pathway” network for the prevention and treatment of chronic bronchitis. The network topology was also analyzed. RESULTS： The network analysis indicated that there were 13 active components in TFH， such as quercetin， ent-epicatechin and quercetin-3-methylethter， which could interact with 30 potential targets， such as PIK3CG， PRKCA， ALOX5， etc. Above targets were mainly distributed in cell membrane and cytoplasm. TFH played prevention and treatment effect through biological processes as protein amino acid phosphorylation reaction， signal transduction， and molecular functions such as protein binding， transferase activity regulation. Above targets involved 64 pathways in total. Top 10 pathways in the list of target enrichment number were Fc epsilon RI signaling pathway， VEGF signaling pathway， MAPK signaling pathway， T cell receptor signaling pathway， glioma， ErbB signaling pathway， Toll-like receptor signaling pathway， natural killer cell mediated pathway， non-small cell lung cancer and focal adhesion. There were 107 nodes， 449 edges， 8.299 flatness and 0.411 network centricity in the “component-target-pathway” network for the prevention and treatment of chronic bronchitis. Fc epsilon RI signaling pathway， VEGF signaling pathway and MAPK signaling pathway were the core pathways of this network （node degree≥9， intermediary centrality＞0.001）. MAPK1， PIK3CG and AKT1 were the core targets of the network （node degree≥40， intermediary centrality＞0.1）. CONCLUSIONS： The effective components of TFH as quercetin， ent-epicatechin， quercetin-3-methylethter act on the targets of MAPK1， PIK3CG and AKT1 through Fc epsilon RI signaling pathway， VEGF signaling pathway and MAPK signaling pathway， and then play a role in the prevention and treatment of chronic bronchitis.