OBJECTIVE： To observe clinical efficacy and safety of flupirtine maleate combined with meloxicam for postoperative analgesia in patients undergoing mitral valve replacement via anterior median incision. METHODS： A total of 200 patients received mitral valve replacement via anterior median incision were selected from our hospital during Jan. 2017-Jun. 2018. They were divided into control group and observation group according to random number table， with 100 cases in each group. Control group was given Tramadol hydrochloride sustained-release tablets 0.1 g orally， bid+Meloxicam tablets 7.5 mg， qd on the first day after surgery. Observation group was given Flupirtine maleate capsules 0.1 g， tid+Meloxicam tablets 7.5 mg， qd， orally. Both groups were treated for one week. If the patient suffered from sudden pain during the treatment， a single intramuscular injection of Tramadol hydrochloride injection 0.1 g was used for remedial analgesia. VAS scores， satisfaction of postoperative analgesia， the contents of serum inflammatory indexes， the occurrence of ADR and remedial analgesia were observed in 2 groups after surgery. RESULTS： During research， no patient withdrew from the study in either group. Forty-eight to one hundred and sixty-eight hours after surgery， VAS scores and the contents of serum inflammatory indexes in 2 groups were significantly lower than 24 h after surgery， VAS scores （48-144 h after surgery） and the contents of serum inflammatory indexes （24-168 h after surgery） in observation group were significantly lower than control group （P＜0.05）. The satisfaction degree of postoperative analgesia in observation group was 85.00％， which was significantly higher than 60.00％ of control group （P＜0.05）； the incidence of ADR was 8.00％， which was significantly lower than 20.00％ of control group （P＜0.05）. Several patients in both group 24， 48 and 72 h after surgery as well as control group 96 h after surgery needed remedial analgesia， and all received remedial analgesia once， tramadol 0.1 g each time. There was no statistical significance in the incidence of remedial analgesia between 2 groups at above time points （P＞0.05）. CONCLUSIONS： Compared with tramadol combined with meloxicam， flupirtine maleate combined with meloxicam shows better effect for postoperative analgesia in patients undergoing mitral valve replacement via arterior median incision with safety.