OBJECTIVE： To illustrate the application of evidence quality evaluation methods in the practice of clinical pharmacy and then promote clinical rational use of drugs. METHODS： The standardized process of evidence quality evaluation formulated by clinical pharmacists of our hospital （Huaihua First People’s Hospital） on the basis of evidence-based medicine was introduced [mainly including evidence quality grading and recommended density system of GRADE （Grades of Recommendations Assessment， Development and Evaluation）]. The application of the process was described through 3 projects of clinical pharmacy practice as medical order review， new drug purchase and drug consultation. RESULTS & CONCLUSIONS： The process of evidence quality evaluation in our hospital was as follows： Firstly， find preferentially authoritative guides and references， drug package inserts and related studies， etc. Then， use the GRADE system to quantify the quality of existing evidence when no high-level evidences were found. Lastly， medication advices could be given timely and accurately. The scores of 3 cases according to GRADE system were≤－3 points， ＝－2 points， ≤－3 points， respectively. Corresponding evidence levels were successively D level （very low level evidence）， C level （low level evidence） and D level. Further， recommended strengths were no recommendation， weak recommendation and strong recommendation against drug treatment programs. Clinical pharmacists make use of the above-mentioned standardized quality evaluation methods in clinical work， so as to provide reasonable medication recommendations for clinical practice.