OBJECTIVE： To provide reference for improving clinical study of Tibetan medicine. METHODS： Retrieved from PubMed， Embase， Cochrane Library， CBM， CNKI， VIP and Wanfang database， randomized controlled trials （RCTs） about Tibetan medicine were collected. After data extraction and quality evaluation of included standard， clinical study of Tibetan medicine was evaluated comprehensively. RESULTS： A total of 235 literatures were included， involving 29 177 subjects. From aspect of literature number， the average annual publication of RCT literature related to Tibetan medicine was 8.39±8.12 during 1989-2016. According to International Classification of Disease-10 （ICD-10）， the research diseases focuses on 18 systems including digestive system， muscle/skeletal system and connective tissue， and circulatory diseases，etc. The main single diseases include 33 kinds ，including peptic ulcer， atrophic ulcer and rheumatoid arthritis，etc. Involved drugs were mainly Duyiwei capsules， Qizheng xiaotong plaster， Zuozhu daxi， RPCJ， Zhenzhu qishi， etc.； the unreported ADR literature was 163， accounted for 69.36％， and the units which published Tibetan medicine-related literatures were widespread and scattered in provinces. From aspect of quality index， 4 literatures were published by journals included in SCI； 20 literatures were published by journals included in Guide to the Core Journals of China； 97 literatures were published by core journals of Chinese scientific and technological papers statistics source； 114 literatures were published by non-core journals. Literature quality of Cochrane collaboration network bias risk evaluation tool 5.1.0  showed that quality of studies was poor. There were small number of references （median number of 3）， less participants （median number of 1）， low support rate of the research project fund （17 fund literatures， 7.23％）， small number of provincial cooperation studies （22 literatures， 9.36％）. The methodology of the overall study needed to be further improved. CONCLUSIONS： There are many problems in clinical study of Tibetan medicine， such as a small quantity， low quality of existing study， unscientific setting of outcome indicators， insufficient attention to ADR. In the future， it is necessary to strengthen the training of Tibetan medicine research talents， so as to speed up the research and development of Tibetan medicine.