OBJECTIVE： To establish HPLC fingerprints of Tingli shengmai oral liquid. METHODS： HPLC method was adopted. The determination was performed on YMC J’sphere ODS-H80 column with mobile phase consisted of acetonitrile-0.1％ phosphoric acid solution （gradient elution） at the flow rate of 1.0 mL/min. The detection wavelengths were 203 nm and 270 nm， respectively. The column temperature was 30 ℃， and the sample size was 30 μL. Using salvianolic acid B as reference， HPLC chromatograms of 10 batches of sample were established. TCM Chromatogram Fingerprint Similarity Evaluation System （2004 A） was used to evaluate the similarity so as to confirm common peak. RESULTS： There were 21 common peaks in HPLC chromatograms of 10 batches of samples at 203 nm， and 17 common peaks at 270 nm. The similarity was 0.981-0.999. After validation， HPLC chromatograms of 10 batches of sample were good in agreement with control fingerprint. CONCLUSIONS： Established fingerprints can provide reference for quality evaluation of Tingli shengmai oral liquid.