OBJECTIVE： To improve the quality standard of Xipayi mzibizi oral liquid. METHODS： TLC was used to identify Gardenia jasminoides，Euryale ferox， Dioscoreae Spongiosae Rhizoma， Rosa laevigata， Morus alba， qualitatively. The content of geniposide in the preparation was determined by HPLC. The determination was performed on Waters Cosmosil C18 column with mobile phase consisted of methanol-water （gradient elution） at the flow rate of 1.0 mL/min. The detection wavelength was set at 240 nm， and column temperature was 30 ℃. The sample size was 10 μL. RESULTS： TLC spots of G. jasminoides，E. ferox， Dioscoreae Spongiosae Rhizoma，R. laevigata， M. alba were clear and well-separated without interference from negative control. The linear range of geniposide were 9.9～198.0 μg/mL （r＝0.999 9）. The limit of quantitation was 9.9 μg/mL； the recoveries were 97.30％-101.09％ （RSD＝1.35％， n＝6）. RSDs of inter-precision， stability and reproducibility tests were all lower than 2％. RSDs of durability tests were lower than 2％. CONCLUSIONS： Established standard can be used for quality control of Xipayi mzibizi oral liquid.