OBJECTIVE： To provide reference for rational use of antihypertensive drugs in clinic. METHODS： In retrospective study， antihypertensive drug prescriptions were randomly selected from cardiovascular medicine department of Guangdong Provincial People’s Hospital during Jan.-Dec. 2016， by using prescription comment system. The patient’s gender， age， diagnosis， name and pharmacological classification of antihypertensive drugs were counted. Combined use of antihypertensive drugs was compared with the plan recommended by domestic and foreign hypertensive prevention and treatment guidelines. The rationality of antihypertensive drug use was evaluated. RESLUTS & CONCLUSIONS： Totally 4 308 prescriptions of antihypertensive drugs were collected， among which there were 2 183 prescriptions of drug combination， accounting for 50.67％ of total. Among drug combination， there were 1 420 prescriptions of two-drug combination， accounting for 65.05％ of drug combination prescriptions； the most prescriptions contained ARB， accounting for 74.94％ of drug combination prescriptions； 1 627 prescriptions of drug combination were agree with plans recommended by guidelines， accounting for 74.53％ of drug combination prescriptions； there were 420 prescriptions of irrational drug combination， accounting for 19.24％ of drug combination prescriptions. The effectiveness and safety of the prescriptions of drug combination which were not recommended by guidelines need to be further verified due to absence of detailed medical records.