OBJECTIVE： To observe the therapeutic efficacy of active immunization combined with dydrogesterone in the treatment of recurrent abortion， and its effects on serum levels of leptin（LP） and adiponectin（ADPN）. METHODS： Totally 103 patients with recurrent abortion from department of gyhecology， Jinan Third People’s Hospital during Nov. 2015 to Nov. 2016 were selected as trial group， and then divided into trial group one （n＝51） and trial group two （n＝52） according to admission order. Other 100 normal pregnant women were taken as control group. Trial group one was given active immunization combined with dydrogesterone， including that lymphocytes from the patients’ spouse were injected subcutaneously into the patient， every half a month， 3 times of active immunization as a course of treatment， and was given Dydrogesterone tablet 10 mg after pregnancy， bid， until 3 months after the pregnancy. Trial group two was given Dydrogesterone tablet 10 mg， bid， until 3 months after the pregnancy. The serum levels of β-HCG， LP and ADPN were compared between trial group and control group at admission， the serum levels of β-HCG， LP， ADPN and pregnancy outcome （recurrent abortion， full-term pregnancy and successful delivery rate） was compared between 2 trial groups after treatment. RESULTS： At admission， the serum levels of β-HCG， LP and ADPN in trial group were significantly lower than control group. After treatment， the levels of β-HCG， LP and ADPN， successful delivery rate and full-term pregnancy rate in trial group one were significantly higher than trial group two， recurrent abortion rate was significantly lower than trial group two， with statistical significance （P＜0.05）. No adverse reactions were observed in the study. CONCLUSIONS： The use of active immunization combined with dydrogesterone can significantly improve the serum levels of LP and ADPN as well as pregnancy outcome， with good safety.