OBJECTIVE： To put forward relevant suggestions for formulating and implementing medical insurance budget impact analysis （BIA） research guideline in China. METHODS： The medical insurance BIA guidelines or relevant documents were retrieved from ISPOR， Canada and the United States. Their similarities and differences were compared. The experiences of them were summarized in respects of research framework， data source and report format of medical insurance BIA. RESULTS & CONCLUSIONS： ISPOR， Canada， USA and other guidelines or relevant documents have some similarities in normalization requirements of research perspectives， target population calculation based on natural reason and epidemiological data， 3-5 years as the research time limit and some other respects. But the calculation of additional costs as drug price addition， distribution fee should be specifically adjusted according to the unique characteristics of the health systems of countries or regions. Based on the actual conditions of our own health care system， our country can draw up the guidelines for medical insurance BIA impact analysis， which contain model design， research perspective， target population， current use of intervention measures， prediction on the effects of new intervention measure introduction on the market， cost， time range， discount and uncertainty analysis of current and new interventions， situational analysis and verification， so as to better play its role in the formulation and adjustment of medical insurance catalogues and in drug price negotiations.