OBJECTIVE： To reduce the risk of occupational exposure during hazardous drugs deployment in pharmacy intravenous admixture service （PIVAS）. METHODS： Failure mode and effect analysis （FMEA） was used to analyze the failure mode （FM） of occupational exposure during hazardous drugs deployment in PIVAS. The severity， possibility and detectability degree of the FM were scored， and the risk priority number （RPN）； FM that should be given priority improvement were quantified and determined； improvement measures were developed and conducted. After 3 months of improvement management， the risk of occupational exposure was evaluated again， and then RPN was compared before and after improvement. RESULTS： In hazardous drugs deployment links of PIVAS， 9 high-risk FM had been found in total， such as poor drug administration （RPN was 24）， inadequate preparation before deployment （RPN was 24）， incorrect method of deployment （RPN was 45）， improper disposal of waste （RPN was 36）， non-standard handover of hazardous drugs （RPN was 32）， etc. Thus risks control measures had been formulated， including formulating and implementing related system， enhancing operational training， standardizing operating procedure， enhancing supervision and inspection， raising awareness of protection and so on. After 3 months of intervention， RPN of the above 5 FM were reduced to 8， 8， 10， 8， 8， respectively， which were all in a relatively low risk area. Accumulated RPN was reduced from 215 to 54，with statistical significance（P＜0.05）. CONCLUSIONS： The application of FMEA management method in PIVAS of our hospital has reduced the risks of occupational exposure in hazardous drugs deployment.