OBJECTIVE： To provide reference for rational use of trimetazidine in clinic. METHODS： Clinical application of trimetazidine in our hospital during Jan.-Jun. 2017 was analyzed retrospectively to evaluate the rationality of trimetazidine use. RESULTS： Totally 3 934 patients received trimetazidine and mainly aged 60-80 year old； the male was more than female； main type of disease was coronary heart disease； main departments were cardiovascular medicine department， cardiovascular surgery department and geriatric department. There were 1 252 rational cases （accounting for 31.82％） and 2 682 irrational cases （accounting for 68.18％）. Main manifestations of irrational drug use included hyper-indication medication （1 163 cases， 43.36％）， contraindication （119 cases， 4.44％）， unsuitable medication timing （1 180 cases， 44.00％）， unsuitable usage and dosage （rational indications without contraindication， 220 cases， 8.20％）. CONCLUSIONS： In our hospital， there is still obvious unreasonable use of trimetazidine in the patients. The clinicians should strictly grasp the indications and contraindications. It is necessary to deliver the latest medication information to clinicians in a variety of ways. The clinicians also should provide rational drug use education， inhibit the indications， usage and dosage of trimetazidine by means of information method， and take a variety of measures to ensure the safety of the patients.