OBJECTIVE： To shorten medicine dispensing time reduce dispensing error rate and improve work efficiency of pharmacists in central pharmacy of our hospital. METHODS： Automatic medicine packaging machine （ATC） coupled with Automatic medicine detection machine （MDM） dispensing mode （ATC-MDM series dispensing mode） were used to dispense oral medicines for inpatients of our hospital. Using dispensing time， the number of daily packaging， number of pharmacist， accuracy of wrong medicine package identification as indexes， the effects of ATC-MDM series dispensing mode and ATC dispensing mode were compared and analyzed. RESULTS： Compared with ATC dispensing mode， ATC-MDM series dispensing mode could not be influenced by medicine type and number， and the time of medicine dispensing was shortened by about 1.5 h per person； labor cost was decreased by 2 persons； the number of daily packing was increased by about 500 packages. The rate of automatic wrong medicine package detection reached 100％， and accuracy of medicine packaging was improved. The data of medicine checking could be automatically saved and generated management reports. CONCLUSIONS： ATC-MDM series dispensing mode can shorten medicine dispensing time， reduce the rate of dispensing error and contribute to the improvement of pharmacist’s work efficiency.