OBJECTIVE：To evaluate clinical program and therapeutic efficacy of imipenem by using T＞MIC calculation model under different T＞MIC. METHODS： By retrospective method， 107 patients underwent blood concentration monitoring of imipenem were collected from China-Japan Friend Hospital during Oct. 2015-Jun. 2017. General information and drug use were recorded.     T＞MIC of imipenem in different patients receiving different programs was calculated according to T＞MIC calculation model by using SPSS 19.0 software. According to different T＞MIC， those patients were divided into ≤40％ group， ＞40％-70％ group， ＞70％-100％ group and ＞100％ group. Medication duration of imipenem use and the percentage of PCT decrease were compared among those groups. RESULTS： Totally 97 patients were included in the study. There were 18 cases in ≤40％ group， 35 cases in ＞40％-70％ group， 34 cases in ＞70％-100％ group and 10 cases in ＞100％ group. There was no statistical significance in baseline level of the body among 4 groups （P＞0.05）. The medication duration of imipenem use were （10.7±2.69），（8.71±3.48），（8.50±4.21） and （9.00±4.87） d， respectively. The percentage of PCT decrease were （37.00±28.83）％，（53.43±21.66）％，（58.67±16.53）％ and （47.25±24.71）％， respectively. CONCLUSIONS： When imipenem is used for anti-infection treatment， that therapy program is adjusted to maintain T＞MIC between ＞70％-100％ may achieve good antibacterial efficacy.