OBJECTIVE： To explore the model and key points of pharmaceutical care provided by nutrition support pharmacists in comprehensive management of nutrition support therapy for critically ill patients， and promote their positive role in clinical rational drug use. METHODS： Through nutrition support pharmacists participated in nutrition treatment management and case analysis of 107 high risk critically ill patients， construction process and implementation points of the “all-in-one” mode of nutrition pharmaceutical care were expounded. RESULTS： The construct procedure of “all-in-one” mode of nutrition pharmaceutical care included that patient selection， establishment of nutrition treatment files， formulation and implementation of “all-in-one” pharmaceutical care plan， nutrition treatment plan optimization and adjustment， records of nutrition treatment related data and file. The key points of mode implementation included standardization and individuation， integration and refinement， safety and effectiveness， specialization and teamwork. In typical cases， pharmacists adjusted the nutrition treatment plan， played their professional expertise， found， prevented and solved the problems of nutrition treatment for critically ill patients effectively. In 107 practice cases， 41 patients transferred to enteral nutrition from parenteral nutrition； 11 patients had cost reduction of nutritional medications； common complications in several patients such as abnormal blood glucose， abnormal blood lipid and liver function injury had been prevented and controlled. CONCLUSIONS： The nutrition support pharmacists， as the member of the multidisciplinary medical team， provide over-all pharmaceutical care， which improves the safety， effectiveness and economy of nutrition support therapy in critically ill patients and proves the core value and function of clinical pharmacy.