OBJECTIVE： To establish a method for simultaneous determination of zinc oxide and 13 metallic element impurities in calcined calamine. METHODS： After microwave digestion of nitric acid and hydrofluoric acid， inductively coupled plasma atomic emission spectrometry （ICP-OES） was used to determine the content of various metallic element in calamine with emssive power of 1 300 W， carrier gas current flow of 15 L/min， auxiliary gas current flow 0.1 L/min， peristaltic pump flow of 0.8 L/min， atomizing air current flow of 0.8 L/min， atomizer pressure of 315 kPa and axial observation at different wavelengths. RESULTS： The linear range of Al， As， Ba， Ca， Cd， Co， Cr， Cu， Fe， Hg， Mg， Mn， Pb， Zn in calamine were 0.001-4.000 μg/mL （r were 0.999 2-0.999 8）. The quantitation limit ranged 0.000 7-0.044 0 μg/mL， detection limits ranged 0.000 2-0.013 2 μg/mL. RSDs of intermediate precision， stability and repeatability tests were all lower than 4％. The recoveries were 86.1％-116.9％ （RSDs were 0.9％-3.6％）. RSDs of durability tests were all lower than 5％. CONCLUSIONS： The method is simple， accurate， precise， stable， reproducible and durable， and it is can be used for simultaneous determination of zinc oxide and 13 metallic element impurities in calcined calamine.