OBJECTIVE： To systematically evaluate the availability level of medicine after the implementation of essential medicine system in China. METHODS： The literatures about the availability of medicine after the implementation of essential medicine system in China were retrieved from CBM， CNKI， VIP and Wanfang databases during 2009-2017. After data extraction of included literatures which met inclusion criteria， Meta-analysis was performed by using Stata MP 14.0 software （including general availability of medicine， availability of essential medicines， regional availability of public hospital， retail pharmacy and primary medical institution）. RESULTS： 13 literatures were included in this study. Results of Meta-analysis showed that combined value of general availability of medicine was 43.4％ [95％CI（35.8％， 51.3％）]； combined value of availability of essential medicines were 43.6％ [95％CI（34.8％， 52.8％）]. The combined value of regional availability of public hospital was 42.3％ [95％CI（22.9％， 55.6％）]； that of retail pharmacy was 45.3％ [95％CI（36.4％， 55.5％）]； that of primary medical institution was 55.0％ [95％CI（46.9％， 63.0％）]. CONCLUSIONS： The availability of essential medicines in our country reached a expected， intermediate level.