OBJECTIVE： To observe the effects of Alprostadil dried emulsion for injection combined with Butylphthalide soft capsules on nerve function， inflammatory factor and coagulation function of patients with severe ischemic stroke. METHODS： A total of 66 patients with severe ischemic stroke selected from our hospital during Jun. 2015-Oct. 2017 were divided into control group and observation group according to random number table， with 33 cases in each group.  On the basis of routine treatment， control group was additionally given Butyphthalide soft capsules 0.2 g/time， orally at fasting state， tid. On the basis of control group， observation group was additionally given Alprostadil dried emulsion for injection 10 μg added into 0.9％ Sodium chloride injection 10 mL， via slow infusion or slow dripping with pipkin， qd. Both groups were treated for 14 days. NIHSS and Barthel index scores， the levels of serum inflammatory factors （CRP， PCT） and coagulation function indexes （D-D， TT， PT， APTT， FIB） were observed in 2 groups before and after treatment， and the occurrence of ADR was also recorded. RESULTS： Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. After treatment， NIHSS scores， the levels of CRP， PCT， D-D and FIB in 2 groups were deceased significantly， while Barthel index scores were increased significantly， TT， PT， APTT were prolonged significantly； observation group was significantly better than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Alprostadil dried emulsion for injection combined with Butylphthalide soft capsules can effectively improve nerve function and coagulation function of patients with severe ischemic stroke， and reduce the levels of inflammatory factor with good safety.