OBJECTIVE： To improve the PIVAS quality management， reduce dispensing error and promote the safety of drug use. METHODS： The quality control circle （QCC） was used for quality management in PIVAS of our hospital. The reasons for dispensing errors were analyzed to determine the key improvement points using “the reduction of dispensing error of admixture drugs” as theme. Improvement plan was formulated， and effective countermeasures were determined by PDCA （Plan， Do， Check， Action） cycle management. The tangible results （the rate of dispensing errors） and intangible results were compared before （Feb. 2016） and after QCC （Aug. 2016）. RESULTS： Some effective measures were formulated and implemented， including unified arrangement， introducing PIVAS MATE process management software， personnel post training， refining drug withdrawal management， visual management， etc. The tangible results included the rate of dispensing error decreased from 1.81‰ to 0.53‰； the rate of goal achievement reached 108.47％； the rate of target progress was 70.72％. The intangible results included optimizing drug dispensing process， standardizing drug withdrawal systent and personal training system. Those achievement improved confidence， responsibility， sense of cooperation and cohesiveness of QCC members. Additional result was obtained， i.e. utility model patent for avoiding light storage box. CONCLUSIONS： QCC can effectively improve the management quality of PIVAS workflow and the safety of intravenous medication.