OBJECTIVE： To establish a method for simultaneous determination of hyperoside， quercitrin， luteoloside， kaempferol， quercetin， rutin， luteolin and isorhamnetin in total flavanones of Sedum sarmentosum Bunge. METHODS： UPLC-MS/MS method was adopted. The determination was performed on ZOBAX SB C18 column with mobile phase consisted of methanol-5 mmol/L ammonium formate aqueous solution （45 ∶ 55， V/V） at the flow rate of 0.4 mL/min. The column temperature was 30 ℃， and sample size was 2 μL. The electrospray ionization source （ESI） was used； ion source temperature was 400 ℃； desolvation temperature was 300 ℃； desolvation gas flow was 600 L/h； capillary voltage was 3 000 V； nebuliser pressure was 45 psi； the work mode was multiple reaction monitoring mode； detection mode was negative ion mode. The established method was used to determine the contents of 8 components in 3 batches of total flavanones of Sedum sarmentosum Bunge. RESULTS： The linear ranges of hyperoside， quercitrin， luteoloside， kaempferol， quercetin， rutin， luteolin and isorhamnetin were 10.0-640.0， 0.5-32.0， 4.5-288.0， 8.0-512.0， 50.0-3 200.0， 2.0-128.0， 12.5-800.0 and 25.2-1 612.8 ng/mL （r≥0.991 4）， respectively. The limits of detection were 5.0， 0.25， 2.25， 4.0， 25.0， 1.0， 6.25 and 12.6 ng/mL， respectively. The limits of quantitation were 10.0， 0.5， 4.5， 8.0， 50.0， 2.0， 12.5 and 25.2 ng/mL， separately. RSDs of precision， stability （24 h） and reproducibility tests were no more than 4.3％ （n＝6）. The recoveries were 95.9％-100.6％， and RSDs were 1.5％-3.8％ （n＝6）. The contents of hyperoside， quercitrin， luteoloside， kaempferol， quercetin， rutin， luteolin and isorhamnetin in 3 batches of total flavanones of Sedum sarmentosum Bunge were 507.88-560.37， 42.95-50.36， 63.52-71.80， 1 695.10-1 753.27， 10 569.28-10 612.99， 25.76-30.13， 2 795.22-2 877.43 and     4 869.55-4 971.30 μg/g， respectively. CONCLUSIONS： The established method can be used for simultaneous determination of 8 components in total flavanones of Sedum sarmentosum Bunge.