OBJECTIVE： To explore the effectiveness and necessity of pharmacists providing medication instruction for discharged patients in therapy management. METHODS： The situation of discharged medication in medical practice was analyzed. The methods and processes of medication instruction for discharged patients in our hospital were elaborated， and the current situation and effectiveness of medication education were conducted. The related consequences and experiences were summarized. RESULTS & CONCLUSIONS： There were some problems， such as the process of drug taking out of hospital was simple and irrationalities of use of drug was found； medical staff lacked professional knowledge of drugs； patients had poor awareness of medication safety. The scope of medication instruction provided by pharmacists in our hospital included prescription checking and education， among which education involved the improvement of medication guidance materials， pharmacists participating in the clinical treatment， etc. In the above process， the discharged patients had high satisfaction with the propaganda and education work of our hospital， and hoped that pharmacists would provide more propaganda and education about ADR. Medication instruction for discharged patients indicated the direction for our hospital to further optimize and improve the pharmacists’ working mode， and deepened the trust between doctors and patients. Publicity materials had become the safe medication principle for patients after discharge. Medication instruction for discharged patients plays a pivotal role in drug therapy management， which is an effective method to promote rational drug use in discharge patients.