OBJECTIVE： To standardize and guide the formulation process of guideline and guarantee the evidence-based formulation of Rapid Advice Guideline for Intravenous Azithromycin in Pediatrics scientifically. METHODS： The protocol of the guideline was introduced， such as guideline-making institution and registration， establishment of project group， scope of application， declaration of interest and funding support， identification of the clinical issues and outcome indexes， evidence retrieval and processing， invastigation of patients preferences and values， economics analysis， development of recommendation， external review and approval， guideline release， dissemination and update， etc. RESULTS： The construction of guidance committee， expert group and secretarial group， the registration （registration number：IPGRP-2016CN013） of the guideline had been achieved according to this protocol； clinical issues （such as indications， usage and dosage， ADR and treatment， drug use in special population） and effectiveness， safety outcome indexes had been formed. The recommendations have been issued by the end of 2017； the full text and interpretation of the guideline will be published in 2018； the guideline will be updated in 2022. CONCLUSIONS： This protocol provides the methodological and programmatic guide and provides reference for evidence-based formulation of the guideline scientifically so as to promote clinical rational drug use.