OBJECTIVE： To provide suggestions for the development of drug circulation enterprises under “two invoice system”. METHODS： By analyzing the negative effects of “multi invoice system” on drug circulation enterprises and positive effects of “two invoice system” on drug circulation enterprises， the development direction of drug circulation enterprises was investigated under “two invoice system”. RESULTS & CONCLUSIONS： The “multi invoice system” formulates the high drug price， causes high drug circulation cost and is difficult to check drug quality. The “two invoice system” standardizes the order of drug circulation field， saves medical drug source， reduce drug price and kept capital chain stable. Under “two invoice system”， drug circulation enterprises should actively adapt to the transformation of medical and pharmaceutical market， and reconstruct the chain of drug circulation. The integration of medical circulation network should be established between the relevant departments and various subjects. Drug circulation subjects should promote the check of ticket， account and goods， standardize the date of back account， implement reform stably.