OBJECTIVE： To optimize the extraction technology of Bushen yangxue granules， and to provide reference for developing hospital preparations. METHODS： The orthogonal test was designed to optimize the extraction technology of Bushen yangxue granules using the comprehensive score including the content of hyperoside and total flavonoids， extract yield as evaluation indexes， water amount， extraction time and extraction times as factors. Verification test was also conducted. RESULTS： The extraction technology of Bushen yangxue granules was 10-fold water， extracting for 2 times and 1 hour each time. The results of verification test indicated that the contents of hyperoside and total flavonoids were 0.154 mg/g （RSD＝0.010％， n＝3） and 11.094 mg/g（RSD＝0.008％， n＝3）. The average extract yield was 37.76％ （RSD＝0.008％，n＝3）. CONCLUSIONS： The optimized extraction technology is stable and feasible， which can provide the basis for developing hospital preparations of Bushen yangxue granules.