OBJECTIVE： To reduce drug repercussion of outpatient pharmacy， and to promote safe drug use. METHODS： By quality control circle （QCC）， the data of drug repercussion were selected from outpatient pharmacy of our hospital in Sept. 2016. The drug repercussion reason check list was designed to master the situation of drug repercussion in outpatient department， formulate improvement measures and confirm effect through field inspection. The case number of drug repercussion and the improvement of circle members’ ability were compared one month before and after QCC （Mar. 2017）. Finally， the effects of QCC were evaluated. RESULTS： Referring to the reasons for the repercussion of adjunct drugs for inspection and the repercussion of unsuitable drug use in our hospital， those problems were improved by formulating manual for drug use examination project， optimizing and examining drug delivery process in the department， etc. The case number of drug repercussion in outpatient pharmacy decreased from 31 cases per month to 12 cases per month； the rate of goal achievement was 119％； the rate of improvement was 61％. The ability of QCC members to solve problems and the ability to use QCC skills were increased positively. CONCLUSIONS： The development of QCC activity in our hospital reduces case number of drug repercussion and optimizes drug delivery process in outpatient pharmacy， and promotes safe drug use.