OBJECTIVE： To establish a method for content determination of total saponins and platycodin D in Platycodon grandiflorum from Sichuan and investigate the difference of 2 indexes in P. grandiflorum from Sichuan of different cultivated years. METHODS： The content of total saponins in P. grandiflorum from Sichuan was determined by UV spectrophotometry. The content of platycodin D was determined by HPLC. The contents of total saponins and platycodin D were compared among each 10 samples of annual， biennial and triennial P. grandiflorum from Sichuan. RESULTS： Average contents of total saponins in annual， biennial and triennial P. grandiflorum from Sichuan were 2.47％， 3.01％， 2.47％， respectively； average contents of platycodin D were 0.23％， 0.27％， 0.33％， respectively. The contents of 2 indexes in annual P. grandiflorum from Sichuan were in relative low level， while the content total saponins in biennial P. grandiflorum from Sichuan was the highest； the content of platycodin D in triennial P. grandiflorum was the highest. CONCLUSIONS： The contents of indexes are different among P. grandiflorum from Sichuan of different cultivated years. But there is no correlation between them. It is suggested to select biennial and triennial P. grandiflorum from Sichuan.