OBJECTIVE： To screen the agonist active ingredients of peroxisome proliferator-activated receptor-γ （PPAR-γ） in flavonoids from Artemisia ordosica， and provide reference for finding antidiabetic agents in A. ordosica. METHODS： Using known PPAR-γ agonist rosiglitazone as positive control， molecular docking technology was conducted for docking one by one for 18 flavonoids and PPAR-γ targets obtained from A. ordosica. It was compared with binding affinities and binding modes of compounds and PPAR-γ targets， and the possible PPAR-γ agonist ingredients in A. ordosica were screened. RESULTS： 5 flavonoids showed good docking affinities， in which， compound 3 （5，3′ ，4′ -trihydroxy-7-methoxyflavone） showed the highest （－8.3 kcal/mol）. Docking mode analysis showed that the phenol oxygen on ring A and ring B of the flavonoids with LBD active site of PPAR-γ formed one （Tyr327） or two hydrogen bonding （Tyr327， Arg288）， which played an important role in the binding of flavonoids and PPAR-γ and the stability of PPAR-γ conformation. CONCLUSIONS： Results of virtual screening in molecular docking technology indicate that flavonoids （mostly containing multiple free phenolic hydroxyl groups） in can easily form good docking mode and high affinity with PPAR-γ， showing potential antidiabetic activity. The study can provide reference for further research of chemical ingredients for the treatment of type 2 diabetes.