OBJECTIVE： To investigate the utilization and trend of bisphosphonates drugs in patients with bone metastasis of breast cancer from Zhejiang province， so as to provide reference for the further promotion of their rational use. METHODS： The utilization of this type of drugs in 11 hospitals of Zhejiang province during 2010-2015 was analyzed statistically， counted and ranked by using the method of cost ranking analysis and DDDs analysis in the respect of amount， DDDs， DDC， etc. RESULTS： The amount of bisphosphonates drugs was increased steadily in 6 years （increasing greatly in 2011）， increased by 96.26％ in 2015， compared to 2010. Top 3 drugs in the list of amount were Zoledronic acid for injection （imported）， Zoledronic acid for injection （domestic） and Pamidronate disodium for injection. Among them， Zoledronic acid for injection （imported） basically showed an upward trend， while Pamidronate disodium for injection showed decline trend. Top 3 drugs in the list of DDDs were Zoledronic acid for injection （domestic）， Zoledronic acid for injection （imported） and Pamidronate disodium for injection； DDDs of Zoledronic acid for injection （domestic） and Zoledronic acid for injection （imported） were generally on the rise， while that of Pamidronate disodium for injection showed an overall downward trend. B/A value of bisphosphonates ranged 0.33-2.00， among which B/A value of Zoledronic acid for injection （domestic） was 2.00 and that of Zoledronic acid for injection （imported） was 0.50 during 2012-2015. The first and second drugs in the list of DDC were Clodronate disodium for injection and Zoledronic acid for injection （imported）. CONCLUSIONS： The total amount of bisphosphonates drugs in patients with bone metastasis of breast cancer from 11 hospitals of Zhejiang province during 2010-2015 was increased steadily. Some varieties of second and third generation bisphosphonates with definite curative effect， good safety and reasonable price are dominant in clinical use. The selection and use of bisphosphonates is basically reasonable， but price is still the primary factor restricting the further wide application of some varieties.