OBJECTIVE： To change traditional working mode of drug storehouse by applying intelligent system， improve drug storage management， improve work efficiency and quality of drug storehouse， and to provide reference for hospital drug storehouse information management. METHODS： The changes of drug storehouse working mode and management in our hospital were compared before and after the application of intelligent drug storehouse management system. The time taken to complete individual work and the times of error occurrence 12 weeks before and after the application of the system were adopted as indexes to evaluate the effects of the system.  RESULTS： Through the combination of Internet+Internet of things bar code， radio frequency identification， electronic tags， etc.， intelligent drug storehouse management system， which included temperature and humidity management， drug storehouse management， supply chain management three modules， was established in our hospital. Its application improved the drug storehouse working mode and process， strengthened the drug storehouse management in respect of staff， supplier， cold chain drugs and special drugs. Before application， average weekly time-consuming of drug shelfing， bill warehousing， outgoing and deliverying and inventory were （11.92±0.701） h， （13.96±0.752） h， （14.96±0.542） h， （4.58±0.376） h； the times of errors within 12 weeks were 10， 8， 9， 2， respectively. After application of the system， average weekly time-consuming were （9.83±0.718） h，（11.29±0.753） h，（9.91±0.557） h，（3.00±0.316） h， respectively （vs. before application，all P＜0.05）. The times of errors within 12 weeks were 1， 1， 2， 0. CONCLUSIONS： The application of intelligent drug storehouse management system optimizes workflow of drug storehouse in our hospital， strengthens the management of drug storehouse， and improves working efficiency and quality of the drug storehouse.