OBJECTIVE： To analyze the situation of off-indication drug use of drugs for high altitude pulmonary edema （HAPE）， and to provide reference for promoting rational drug use in medical institutions of plateau area and establishing relevant management process. METHODS： By taking “HAPE” “treatment” “Altitude illness” “Treatment” as keywords， retrieving from CNKI， PubMed， Embase database during build up to Sept. 2017， drugs for HAPE were screened and extracted after reading the literatures. Drug package inserts of listed preparations were compared， summarized and analyzed. RESULTS： Drugs for HAPE in literatures were screened， and 16 kinds of drugs were summarized finally as nifedipine， sildenafil， tadalafil， aminophylline， etc. Indication of HAPE was not found in drug package inserts of those listed preparations. CONCLUSIONS： At present， there is a universal phenomenon of off-indication drug use of drugs for HAPE， and it is imminent to regulate the management of off-label drug use in the hospital. It is suggested to improve the off-label drug use management flow of drugs for HAPE so as to promote rational drug use.